ABL111
HomePipelineABL111
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- Pipeline
- ABL111
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- Program Target
- Claudin18.2x4-1BB
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- Disease Indication
- Solid Tumor
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- Development Stage
- Clinical Development
(Phase 1)
- Summary
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ABL111 is a bispecific antibody that targets Claudin18.2, a tumor antigen overexpressed in
gastric- and pancreatic-specific cancer, and 4-1BB, a co-stimulatory receptor with the ability to
induce potent anti-tumor activity. To minimize the usual toxicity associated with monospecific
4-1BB based treatments, ABL111 only activates the 4-1BB pathway when engaged with Claudin
18.2, thus triggering T cell activation and enhancing anti-tumor immunity while minimizing
toxicity. ABL111 shows superior anti-tumor activity in an animal model system compared to
Claudin18.2 alone, 4-1BB alone, and the combination of both Claudin18.2 and 4-1BB, with
immunological memory resistant to any possible recurrence of the cancer cells.
Structure and Mechanism of Action
Claudin18.2 Dependent 4-1BB Activation
Superior Anti-Tumor Effect with Immunological Memory
Increase of effector memory CD8+ T cells and soluble 4-1BB